Tag: faith

India amidst Covid 19

India amidst Covid 19

By subhadra in Covid, Healthcare, Social Reform on September 3, 2020

The COVID-19 pandemic in India is part of the worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first case of COVID-19 in India, which originated from China, was reported on 30 January 2020. India currently has the largest number of confirmed cases in Asia, and has the second-highest number of confirmed cases in the world after the United States, with the number of total confirmed cases breaching the 100,000 mark on 19 May, and 1,000,000 confirmed cases on 17 July 2020. On 29 August 2020, India recorded the global highest spike in COVID-19 cases on a day with 78,761 cases surpassing the previous global highest daily spike of 77,368 cases which was recorded in the US on 17 July 2020.

India’s case fatality rate is among the lowest in the world at 2.41% as of 23 July and is steadily declining. By mid-May 2020, six cities accounted for around half of all reported cases in the country – Mumbai, Delhi, Ahmedabad, Chennai, Pune and Kolkata. As of 24 May 2020, Lakshadweep is the only region which has not reported a case. On 10 June, India’s recoveries exceeded active cases for the first time.

On 22 March, India observed a 14-hour voluntary public curfew at the instance of Prime Minister Narendra Modi. It was followed by mandatory lockdowns in COVID-19 hotspots and all major cities. Further, on 24 March, the prime minister ordered a nationwide lockdown for 21 days, affecting the entire 1.3 billion-person population of India. On 14 April, India extended the nationwide lockdown till 3 May which was followed by two-week extensions starting 3 and 17 May with substantial relaxations. From 1 June, the government started “unlocking” the country (barring “containment zones”) in three unlock phases.

In March, after the lockdown was imposed, the United Nations (UN) and the World Health Organization (WHO) praised India’s response to the pandemic as ‘comprehensive and robust,’ terming the lockdown restrictions as ‘aggressive but vital’ for containing the spread and building necessary healthcare infrastructure. At the same time, the Oxford COVID-19 Government Response Tracker (OxCGRT) noted the government’s swift and stringent actions, emergency policy-making, emergency investment in health care, fiscal stimulus, investment in vaccine and drug R&D and gave India a score of 100 for the strict response. Also in March, Michael Ryan, chief executive director of the WHO’s health emergencies programme noted that India had tremendous capacity to deal with the outbreak owing to its vast experience in eradicating smallpox and polio. Other commentators have raised concerns about the economic fallout arising as a result of the pandemic and preventive restrictions.The lockdown was justified by the government and other agencies for being preemptive to prevent India from entering a higher stage which could make handling very difficult and cause even more losses thereafter.

Cancer research in India: Challenges & opportunities

Cancer research in India: Challenges & opportunities

By subhadra in Cancer, Healthcare, Social Reform on September 2, 2020

With changing lifestyle, improved longevity and better control of infectious diseases, non-communicable diseases have emerged as major health problems worldwide, more so in developing countries. After cardiac diseases, cancer has emerged as an important cause of morbidity and mortality in India. According to The National Centre for Disease Informatics and Research of the Indian Council of Medical Research (ICMR) at Bengaluru, India, 1.45 million cases of cancer were estimated to be diagnosed in 2016. This burden is likely to become double in the next 20 years.

Magnitude & pattern of various cancers in India

The National Cancer Registry Programme was commenced by the ICMR in December 1981 and is a major source of information on cancer incidence and pattern in the country. Currently, there are 29 population-based cancer registries (PBCRs) and 29 hospital-based cancer registries. These cover about 10 per cent of India’s population. Of these, 11 PBCRs are located in the North-East (NE) region. Age-adjusted incidence (per 100,000) rate for males is higher in the West – 631.9 in Brazil, 493.9 in USA – Michigan, compared to India 270.0 in Aizawl district and 149.4 in Delhi. Corresponding figures in females are 474.6 in Brazil, 363.3 in USA, 207.7 in Aizawl and 144.8 in Delhi (India) per 100,000, respectively. The top five cancers among men are lung, head and neck region (mouth, tongue and larynx), prostate and oesophagus. While among women – breast, cervix, ovary, oral cavity and uterine cancer are most common. The incidence of cervical cancer is declining over the past three decades in Delhi, Chennai, Bengaluru, Bhopal, Mumbai and Barshi PBCRs. The incidence of colon/rectum, lung, breast and prostate cancer is gradually rising in these registries.

There is significant geographical variation in the incidence of cancer in India. For example, in the NE region, the incidence of cancer is highest in India, for both sexes. In males, Aizawal district (located in Mizoram) reported highest cases while Papumpare district in Arunachal Pradesh had the highest number in females. Higher incidence of gallbladder cancer in north India and NE region compared to other parts, higher incidence of stomach cancer in Chennai and Bengaluru PBCRs, oesophagus cancer in Kashmir and NE region would indicate different aetiological factors operating, for example, environmental, diet, lifestyle and genetic factors. Nearly 50 per cent of cancers in males and 15 per cent in females are related to the use of tobacco in different forms. These include cancers of aerodigestive tract (head and neck, lung and oesophagus), pancreas and renal and urinary bladder. It is clear that the biggest measure to reduce the incidence of these cancers would be to reduce the consumption of tobacco. Specific cancer research programmes to focus on biology of population present in various States with PBCRs will help determine risk factors responsible and suggest strategies for prevention.

Delay in diagnosis

Almost 75-80 per cent of patients have advanced disease (Stage 3-4) at the time of diagnosis. This has been attributed to the late presentation which in turn is due to low level of awareness in the population and among community physicians, lack of screening programmes, lack of diagnostic facilities locally and vast distances to travel to reach a major tertiary cancer centre, financial constraints and stigma associated with the diagnosis. The situation is even worse in rural areas (69% of total population) where patients and families have to travel a long distance to reach a tertiary care oncology centre. Lack of place to stay, long time taken for investigations, limited finances, language and cultural differences are also some of the limitations. As per data from rural-based PBCRs, the incidence of cancer is low in rural India compared to urban PBCRs. Even the pattern of cancers in rural PBCRs is different compared to those in urban PBCRs, suggesting a different policy/approach to adopt in rural areas.

Infrastructure

One of the major reasons for not being able to implement screening programme in India has been lack of workforce – physicians, health workers, technical staff and pathologist to review pathological material. The preference of healthcare personnel to work in urban settings has also resulted in unequal distribution of healthcare centres and practitioners. Many tertiary care centres (not all) have a comprehensive team of professionals comprising medical, radiation and surgical oncologists, pain and palliative care experts and auxiliary services, for example, diagnostics and pathological tests. A complex team like this is yet to be a reality in rural India.

Available data from randomized trials done in south India suggest that simple innovative methods such as visual inspection-based screening (for oral cavity) , visual inspection with acetic acid application for cervical cancer may be useful and cost-effective methods of screening for these two common cancers. Similarly, for breast cancer self-examination or examination by a physician may be alternative methods to screening mammography which are doable for early detection of breast cancer, as detection in early stages is amenable for treatment with curative option with less morbidity. Ultimately, the screening programmes can bring down the incidence of some of the common cancers in India. There has been effort by the Government of India (GOI) to establish regional cancer centres in rural areas, and upgrade medical colleges with oncology department. Under the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Disease and Stroke, the GOI has allocated ₹ 120 crores each for the establishment of 20 State-level cancer centres. The GOI has also allocated 20 million USD to develop 23 new tertiary care centres and to strengthen 27 regional cancer centres. Under the ‘Pradhan Mantri Swasthya Yojna’, eight new cancer centres would be set up in various parts of country and 58 existing medical colleges would be upgraded in a phased manner. This is a mammoth task and will take some years before this translates into standard care and survival benefit. One solution to this problem might be setting up and improving primary care services in rural areas and educating people about cancer, environmental pollution, clean drinking water, healthy diet and avoid tobacco use. Experienced health practitioner, researchers and physicians should concentrate on early detection of cancer, as cure rates are high, if cancer is detected in early stage.

Several non-government organizations are engaged in increasing public awareness, supporting screening, early detection, patient and family support services and palliative care by providing home care. There is a need to consolidate and strengthen their role in national cancer control programme. Further, the ICMR has taken initiative to publish consensus documents on common cancers in India to improve quality and standardized cancer care. These are expert and evidence-based guidelines to promote uniformity and to ensure the quality of treatment across cancer centres in India. In recent years, the government has tried to address these issues by establishment of the National Health Mission and insurance schemes such as Rashtriya Swasthya Bima Yojna (a central government initiative); Rajiv Aarogyasri Scheme (an Andhra Pradesh government initiative); Vajpayee Arogyashree Scheme (a Karnataka government initiative), and also Gujarat health scheme model. The emphasis is now to educate people about these programmes.

Clinical research

Although a notable progress in this field has been made in the recent years, there is a need to develop proper clinical research environment. This includes exposing graduate and postgraduate medical students, community physicians and medical college teachers about translation clinical research, and developing adequate infrastructure. Indian pharmaceutical industry has made phenomenal growth in the field of generic molecules; they need to invest in the development of new molecules and India centric cancer research.

India has a large pool of individuals with genetic diversity (4000 anthropologically distinct groups and 22 languages). This provides an opportunity to study environmental influences on drug metabolism (such as smoking, alcohol and use of herbal medicine), variation in drug targets (for example, higher incidence of activating mutations of epidermal growth factor receptor in lung cancer in patients from Asia), and genetic polymorphism in drug-related genes. Indian population is unique in terms of genetics, culture, languages and food habits. Well-planned genome-wide association studies may yield insights into disease aetiology and potential responses to therapy. In the era of precision medicine, it will be important to define risks or susceptibility of certain population or ethnic subgroups for high incidence of cancer seen in these areas and also from treatment point of view if these subgroups need dose modification or special precaution during the treatment. Translational studies involving imaging, pathology, gene expression profiling, sequencing, bioinformatics and detection of circulating tumour cells can be done in few centres, and then data generated can be evaluated for its translation at other centres.

Key priority areas for research

One of the important tasks would be to develop consensus on key priorities for cancer research in Indian context based on common cancers in males and females in a particular region. There is a need to focus research on prevention of some cancers with high incidence in certain areas, for example, gallbladder cancer in Gangetic belt, penile cancer in rural population, oesophageal cancer in NE region, colon cancer in Goa, stomach cancer in southern and northeast India. Whether these regional differences in epidemiology are due to a difference in genomics and biology or due to differences in the prevalence of cancer risk factors or both are not yet known and would be an important area of research. These cancers are rare in West and therefore, not a focus for large research programmes. Similarly, directing research for upcoming problems like lifestyle and obesity-related cancers would be timely.

Since most patients have advanced disease and poor performance status at presentation, research efforts to develop cost-effective protocols for palliative care would be meaningful. Developing protocols to less toxic regimens (e.g. metronomic therapy with minimal visits to a busy cancer centre) and minimizing need for imaging (e.g. computed tomography scan) in the follow up would be simple, yet important solutions. An active collaboration between investigators, funding agencies, industry and regulatory bodies would be important to understand needs of each other.

Way forward

Cancer in India is emerging as a major cause of morbidity and mortality. Some of the key features include young age (generally one decade younger compared to the western population), advanced disease, poor performance status and possibly more aggressive phenotype. While many tertiary cancer centres have state of the art diagnostic workup and treatment protocols, this is yet to reach to a standard level in many other regional cancer centres and hospital in smaller towns. Focussing on epidemiological research, screening for certain cancers and clinical trials India-centric common cancers may provide solutions for improvement in outcome. A planned and teamwork approach at the institution level and collaboration with different research teams are likely the key to success.

Initiative to curb Covid-19

Initiative to curb Covid-19

By subhadra on August 16, 2020

Why do the nations rage, and the peoples plot a vain thing? The kings of the earth take a stand, and the rulers take counsel together, against Yahweh, and against his Anointed, saying, «Let’s break their bonds apart, and cast their cords from us.» He who sits in the heavens will laugh. The LORD will have them in derision. Then he will speak to them in his anger, and terrify them in his wrath: «Yet I have set my King on my holy hill of Zion.» I will tell of the decree.

Yahweh said to me, «You are my son. Today I have become your father. Ask of me, and I will give the nations for your inheritance, the uttermost parts of the earth for your possession. You shall break them with a rod of iron. You shall dash them in pieces like a potter’s vessel.» Now therefore be wise, you kings. Be instructed, you judges of the earth. Serve Yahweh with fear, and rejoice with trembling. Give sincere homage to the Son, lest he be angry, and you perish in the way, for his wrath will soon be kindled. Blessed are all those who take refuge in him

A Collective Prayer

A Collective Prayer

By on March 17, 2020

Why do the nations rage, and the peoples plot a vain thing? The kings of the earth take a stand, and the rulers take counsel together, against Yahweh, and against his Anointed, saying, «Let’s break their bonds apart, and cast their cords from us.» He who sits in the heavens will laugh. The LORD will have them in derision. Then he will speak to them in his anger, and terrify them in his wrath: «Yet I have set my King on my holy hill of Zion.» I will tell of the decree.

Yahweh said to me, «You are my son. Today I have become your father. Ask of me, and I will give the nations for your inheritance, the uttermost parts of the earth for your possession. You shall break them with a rod of iron. You shall dash them in pieces like a potter’s vessel.» Now therefore be wise, you kings. Be instructed, you judges of the earth. Serve Yahweh with fear, and rejoice with trembling. Give sincere homage to the Son, lest he be angry, and you perish in the way, for his wrath will soon be kindled. Blessed are all those who take refuge in him

Readings of the New Testament

Readings of the New Testament

By on March 5, 2020

Why do you boast of mischief, mighty man? God’s loving kindness endures continually. Your tongue plots destruction, like a sharp razor, working deceitfully. You love evil more than good, lying rather than speaking the truth. You love all devouring words, you deceitful tongue. God will likewise destroy you forever. He will take you up, and pluck you out of your tent, and root you out of the land of the living. The righteous also will see it, and fear, and laugh at him, saying, «Behold, this is the man who didn’t make God his strength, but trusted in the abundance of his riches, and strengthened himself in his wickedness.» But as for me, I am like a green olive tree in God’s house. I trust in God’s loving kindness forever and ever. I will give you thanks forever, because you have done it. I will hope in your name, for it is good, in the presence of your saints.

The Test of Faith

The Test of Faith

By on March 5, 2020

Blessed is the man who doesn’t walk in the counsel of the wicked, nor stand in the way of sinners, nor sit in the seat of scoffers; but his delight is in Yahweh’s law. On his law he meditates day and night. He will be like a tree planted by the streams of water, that brings forth its fruit in its season, whose leaf also does not wither.

Whatever he does shall prosper. The wicked are not so, but are like the chaff which the wind drives away. Therefore the wicked shall not stand in the judgment, nor sinners in the congregation of the righteous. For Yahweh knows the way of the righteous, but the way of the wicked shall perish.

A Collective Prayer

A Collective Prayer

By on February 28, 2020

Why do the nations rage, and the peoples plot a vain thing? The kings of the earth take a stand, and the rulers take counsel together, against Yahweh, and against his Anointed, saying, «Let’s break their bonds apart, and cast their cords from us.» He who sits in the heavens will laugh. The LORD will have them in derision. Then he will speak to them in his anger, and terrify them in his wrath: «Yet I have set my King on my holy hill of Zion.» I will tell of the decree.

Yahweh said to me, «You are my son. Today I have become your father. Ask of me, and I will give the nations for your inheritance, the uttermost parts of the earth for your possession. You shall break them with a rod of iron. You shall dash them in pieces like a potter’s vessel.» Now therefore be wise, you kings. Be instructed, you judges of the earth. Serve Yahweh with fear, and rejoice with trembling. Give sincere homage to the Son, lest he be angry, and you perish in the way, for his wrath will soon be kindled. Blessed are all those who take refuge in him

Prophetic Conference

Prophetic Conference

By on February 26, 2020

Why do you stand far off, Yahweh? Why do you hide yourself in times of trouble? In arrogance, the wicked hunt down the weak. They are caught in the schemes that they devise. For the wicked boasts of his heart’s cravings. He blesses the greedy, and condemns Yahweh. The wicked, in the pride of his face, has no room in his thoughts for God. His ways are prosperous at all times. He is haughty, and your laws are far from his sight. As for all his adversaries, he sneers at them. He says in his heart, «I shall not be shaken. For generations I shall have no trouble.» His mouth is full of cursing, deceit, and oppression. Under his tongue is mischief and iniquity. He lies in wait near the villages. From ambushes, he murders the innocent. His eyes are secretly set against the helpless. He lurks in secret as a lion in his ambush. He lies in wait to catch the helpless.

He catches the helpless, when he draws him in his net. The helpless are crushed. They collapse. They fall under his strength. He says in his heart, «God has forgotten. He hides his face. He will never see it.» Arise, Yahweh! God, lift up your hand! Don’t forget the helpless. Why does the wicked person condemn God, and say in his heart, «God won’t call me into account?» But you do see trouble and grief. You consider it to take it into your hand. You help the victim and the fatherless. Break the arm of the wicked. As for the evil man, seek out his wickedness until you find none. Yahweh is King forever and ever! The nations will perish out of his land. Yahweh, you have heard the desire of the humble. You will prepare their heart. You will cause your ear to hear, to judge the fatherless and the oppressed, that man who is of the earth may terrify no more.

The Blood of the Martyrs Is Seed

The Blood of the Martyrs Is Seed

By on February 22, 2020

Yahweh, how my adversaries have increased! Many are those who rise up against me. Many there are who say of my soul, «There is no help for him in God.» But you, Yahweh, are a shield around me, my glory, and the one who lifts up my head. I cry to Yahweh with my voice, and he answers me out of his holy hill. I laid myself down and slept. I awakened; for Yahweh sustains me. I will not be afraid of tens of thousands of people who have set themselves against me on every side. Arise, Yahweh! Save me, my God! For you have struck all of my enemies on the cheek bone. You have broken the teeth of the wicked. Salvation belongs to Yahweh. Your blessing be on your people.

Answer me when I call, God of my righteousness. Give me relief from my distress. Have mercy on me, and hear my prayer. You sons of men, how long shall my glory be turned into dishonor? Will you love vanity, and seek after falsehood? But know that Yahweh has set apart for himself him who is godly: Yahweh will hear when I call to him. Stand in awe, and don’t sin. Search your own heart on your bed, and be still. Offer the sacrifices of righteousness. Put your trust in Yahweh. Many say, «Who will show us any good?» Yahweh, let the light of your face shine on us. You have put gladness in my heart, more than when their grain and their new wine are increased. In peace I will both lay myself down and sleep, for you, Yahweh alone, make me live in safety.